Hematological Profile of Pulmonary Tuberculosis and Blood Donor Eligibility
DOI:
https://doi.org/10.56727/bsm.v11i2.168Keywords:
pulmonary tuberculosis, hematological profile, donor eligibilityAbstract
Pulmonary tuberculosis (TB) is an infectious disease that can cause changes in the Hematological profile, particularly in hemoglobin, erythrocyte, leukocyte, platelet, and hematocrit levels. These changes may reflect the patient's inflammatory condition and health status and have implications for the health aspects of prospective blood donors. However, studies linking the Hematological profile in pulmonary TB to blood donor eligibility remain limited. The aim of this study analyzes the Hematological profile in patients with pulmonary TB and identify its implications for blood donor eligibility as well as existing research gaps. This study used a Narrative Literature Review. Literature available in the existing extraction document was reviewed narratively, focusing on pulmonary tuberculosis, hematological profile changes, and their relevance to blood donor eligibility. The literature comprised Indonesian- and English-language publications, mainly from 2021–2026, from sources recorded in the extraction document: PubMed/MEDLINE, ScienceDirect, Google Scholar, Garuda, and SINTA. This review did not use a systematic PRISMA selection process. The literature indicates that pulmonary TB is generally associated with decreased hemoglobin, erythrocyte, and hematocrit levels, as well as increased leukocyte, platelet, and Erythrocyte Sedimentation Rate (ESR). Anemia is the most consistent finding and represents the Hematological parameter most relevant to donor eligibility. Evidence regarding donor eligibility for individuals with a history of cured TB remains limited.Changes in the Hematological profile in pulmonary TB, particularly anemia, should be considered in the health evaluation of prospective blood donors. A history of TB cannot be directly used as a basis for donor ineligibility without considering cure status and current health conditions at the time of donation.
Downloads
References
Adane, T., Melku, M., Ayalew, G., Bewket, G., Aynalem, M., & Getawa, S. (2022). Accuracy of monocyte to lymphocyte ratio for tuberculosis diagnosis and its role in monitoring anti-tuberculosis treatment: Systematic review and meta-analysis. Medicine, 101(44), e31539–e31539. https://doi.org/10.1097/MD.0000000000031539
Ali, A., Wu, L., Moazen, E. M., Elsawy, S. B., Salama, K. S. M., Ullah, K., Elfeky, S. E. F., Alharbi, S. H., & Saleh, M. M. (2024). Hematological profiles and mortality risk in critically ill and drug-resistant tuberculosis patients: insights from a longitudinal study. The Egyptian Journal of Bronchology 2024 18:1, 18(1), 40-. https://doi.org/10.1186/S43168-024-00294-X
Batool, Y., Pervaiz, G., Arooj, A., & Fatima, S. (2022). Hematological manifestations in patients newly diagnosed with pulmonary tuberculosis. Pakistan Journal of Medical Sciences, 38(7), 1968. https://doi.org/10.12669/PJMS.38.7.5911
Clement, M., Shehu, E., & Chandler, T. (2021). The impact of temporary deferrals on future blood donation behavior across the donor life cycle. Transfusion, 61(6), 1799–1808. https://doi.org/10.1111/TRF.16387
Cutts, J. C., Quinn, B., Seed, C. R., Kotsiou, G., Pearson, R., Scott, N., Wilson, D. P., Harrod, M. E., Maher, L., Caris, S., Thompson, A. J., Farrell, M., Pink, J., &
Hellard, M. E. (2020). A Systematic Review of Interventions Used to Increase Blood Donor Compliance with Deferral Criteria. Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie, 48(2), 118–129. https://doi.org/10.1159/000509027
de Mendonça, E. B., Schmaltz, C. A. S., Sant’Anna, F. M., Vizzoni, A. G., Mendes-De-Almeida, D. P., de Vasconcellos Carvalhaes de Oliveira, R., & Rolla, V. C. (2021). Anemia in tuberculosis cases: A biomarker of severity? PLOS ONE, 16(2), e0245458. https://doi.org/10.1371/JOURNAL.PONE.0245458
Dewi, I. G. A. A. S., Sutema, I. A. M. P., Widiantari, N. P., Yanti, N. P. D. M., & Dewi, N. K. S. M. (2025). Profil Hematologi Pada Penderita Tuberkulosis Sebelum Dan Sesudah Pengobatan Oat Di Puskesmas Kota Denpasar. Klinikal Sains : Jurnal Analis Kesehatan, 13(1), 189–204. https://doi.org/10.36341/KLINIKALSAINS.V13I1.5447
Farhadian, M., Veisi, S., Farhadian, N., & Zamanian, M. H. (2024a). Hematological parameters in newly diagnosed TB patients: A systematic review and meta-analysis. Tuberculosis (Edinburgh, Scotland), 144, 102430. https://doi.org/10.1016/j.tube.2023.102430
Farhadian, M., Veisi, S., Farhadian, N., & Zamanian, M. H. (2024b). Hematological parameters in newly diagnosed TB patients: A systematic review and meta-analysis. Tuberculosis, 144, 102430. https://doi.org/10.1016/J.TUBE.2023.102430
Firdayanti, F., Susanti, S., & Nurmina, N. (2024). Profil Hematologi Penanda Anemia Pada Penderita Tuberkulosis Dengan Pengobatan Di Puskesmas Puuwatu Kota Kendari. Journal of Nursing and Health, 9(2), 203–210. https://doi.org/10.52488/jnh.v9i2.367
Gaeddert, M., Glaser, K., Chendi, B. H., Sultanli, A., Koeppel, L., MacLean, E. L., Broger, T., & Denkinger, C. M. (2024). Host blood protein biomarkers to screen for tuberculosis disease: a systematic review and meta-analysis. Journal of Clinical Microbiology, 62(11). https://doi.org/10.1128/JCM.00786-24
Karwiti, W., Sri Lestari, W., Rezekiyah, S., & Kesehatan Jambi, P. (2021). Perbedaan Profil Hematologi Pada Penderita Tuberkulosis Paru Yang Menjalani Pengobatan. Jambura Journal of Health Sciences and Research, 3(1), 126–132. https://doi.org/10.35971/JJHSR.V3I1.8350
Lamba, D. S., Sachdev, S., Hans, R., Krishan Dhawan, H., Sharma, R. R., & Marwaha, N. (2023). Review of blood donor deferral with emphasis on donor and patient safety. Transfusion Clinique et Biologique, 30(1), 56–62. https://doi.org/10.1016/J.TRACLI.2022.07.002
Li, Z., Hu, Y., Wang, W., Zou, F., Yang, J., Gao, W., Feng, S. W., Chen, G., Shi, C., Cai, Y., Deng, G., & Chen, X. (2024). Integrating pathogen- and host-derived blood biomarkers for enhanced tuberculosis diagnosis: a comprehensive review. Frontiers in Immunology, 15. https://doi.org/10.3389/FIMMU.2024.1438989
Ongwae, J. M., Musyoki, S. K., & Mongare, S. (2023). Profile of haematological indices among pulmonary tuberculosis patients attending Kisii teaching and referral hospital, Kenya. International Journal Of Community Medicine And Public Health, 10(8), 2669–2675. https://doi.org/10.18203/2394-6040.IJCMPH20232351
Reta, B., Mohammed, A. E., Tesfaye Kiya, G., Adissu, W., & Shenkute, T. Y. (2023). Impact of anti-tuberculosis treatment on hematological parameters in newly diagnosed tuberculosis patients at Jimma town: a longitudinal prospective study. Annals of Medicine and Surgery (2012), 85(8), 3887–3893. https://doi.org/10.1097/MS9.0000000000001084
Safitri, R. N., Hadi, W. S., & Astuti, T. D. (2024). Gambaran Kadar Hemoglobin Dan Leukosit Pasien Tuberkulosis Paru Yang Mendapat Terapi Obat Anti Tuberkulosis Di Rumah Sakit X. Jurnal Kesehatan Tambusai, 5(4), 10841–10854. https://doi.org/10.31004/JKT.V5I4.34626
Shah, A. R., Desai, K. N., & Maru, A. M. (2022). Evaluation of hematological parameters in pulmonary tuberculosis patients. Journal of Family Medicine and Primary Care, 11(8), 4424–4428. https://doi.org/10.4103/JFMPC.JFMPC_2451_21
Zahidin, M. A., Saidin, N. I. S., Ibrahim, N. A., Mohd Nasir, N. N. A., Abdul Razak, N. I., Ramli, M., Hassan, M. N., & Mohd Noor, N. H. (2024). The Blood Donor Deferral Rate and the Reasons for Deferral at a Tertiary Care Teaching Institute in Northeastern Malaysia. Cureus. https://doi.org/10.7759/cureus.54954
Downloads
Published
Issue
Section
License
Copyright (c) 2026 JURNAL ILMU KESEHATAN BHAKTI SETYA MEDIKA
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Hak cipta artikel dimiliki oleh Jurnal Ilmu Kesehatan Bhakti Setya Medika.